







Joint Health & Mobility Soft Chews For Dogs
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Supports cartilage structure & mobility
Helps reduce stiffness and discomfort
Greater efficacy than Glucosamine & Chondroitin
6 Clinically proven ingredients
Choose your dog's weight
ADD TO CART - $62.99
/2 months
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Supports Joint Mobility

Reduces Stiffness Discomfort

Enhances Cartilage Health

Clinically Proven Formula
Product Facts
Directions of Use

Real Dog Owners. Real Results. Real Stories
Rated 4.5 out of 5 by over 1,000+ pet parents like you.

5 Powerful Reasons Every Pet Parent Needs to Try PupFlex+ for Their Dog’s Joint Health
Watching your beloved pup struggle with stiff joints and reduced mobility is heartbreaking. Every pet parent wants their furry companion to live an active, pain-free life—but finding a truly effective joint supplement can feel impossible.
That’s why thousands of dog owners are turning to PupFlex+, a premium joint support supplement designed to promote long-term mobility, flexibility, and comfort.
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Helps With:
Powerful Antioxidant Protection
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Promoting Mobility & Flexibility
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Joint Pain and Stiffness
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Decreasing Inflammation
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Cushioning and Lubricating Joints
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Supporting Cartilage Structure
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Powerful Antioxidant Protection
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Promoting Mobility & Flexibility
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Joint Pain and Stiffness
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Decreasing Inflammation
|
Cushioning and Lubricating Joints
|
Supporting Cartilage Structure
|
Powerful Antioxidant Protection
|
Promoting Mobility & Flexibility
|
Joint Pain and Stiffness
|
Decreasing Inflammation
|
Cushioning and Lubricating Joints
|
Supporting Cartilage Structure
|
Powerful Antioxidant Protection
|
Promoting Mobility & Flexibility
|
Joint Pain and Stiffness
|
Decreasing Inflammation
|
Cushioning and Lubricating Joints
|
Supporting Cartilage Structure
|
1. Clinically Proven Ingredients for Maximum Joint Support
Not all joint supplements are created equal. PupFlex+ stands out because it’s packed with scientifically backed ingredients, including UC-II® (Undenatured Type II Collagen), CurcuVet® (Curcumin Phytosome®), ApresFlex® (Boswellia Serrata), Antarctic Krill Omega-3 and AstaReal® Astaxanthin.
These powerful actives work synergistically to reduce inflammation, rebuild cartilage, and improve joint function—helping dogs of all breeds, sizes, and ages stay active and pain-free.
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2. Fast-Acting Formula – See Results in Just 3 Weeks
Many pet owners grow frustrated with supplements that take months to show results, if they work at all. But with PupFlex+, most dogs experience noticeable improvements in mobility within just 3-4 weeks! This rapid relief is thanks to high-bioavailability of active ingredients that get to work soothing stiff joints, reducing pain and discomfort, and enhancing flexibility faster than traditional Glucosamine based supplements.
3. Ultimate Joint support and protection for effortless movement
UC-ll® Collagen supports cartilage structure, reduces joint pain by 57% in 30 days, promotes healthy mobility and flexibility. CurcuVet® ( Curcumin Phytosome) reduces joint discomfort and inflammation 29 times more effectively than other curcumin extracts. ApresFlex®( Boswellia Serrata AKBA) relieves joint pain and supports structural integrity of joints and connective tissue. Antarctic Krill is a source of highly bioavailable Omega-3 fatty acids.


4. Powerful Antioxidant Protection to Combat Joint Damage
Inflammation and oxidative stress are major culprits behind joint deterioration. PupFlex+ includes AstaReal® Astaxanthin, one of the most potent antioxidants on the planet, to fight off damaging free radicals and slow down joint wear and tear.
This means stronger, healthier joints for years to come, giving your pup the comfort and mobility they deserve.
5. Perfect for Every Dog – From Playful Puppies to Aging Seniors
Whether you have a high-energy pup, a working dog, or a senior companion slowing down with age, PupFlex+ is formulated to support their joint health at every life stage.
Early supplementation can help maintain flexibility and prevent future issues, while older dogs benefit from reduced stiffness and improved comfort—making every tail wag a little easier.
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The #1 Choice For Pet Parents
See Why 1.4 million customers trust Biopup
Effective joint support
Our oldest dog Molson (7) was diagnosed with arthritis and once he started taking these, we saw a noticeable difference in his mobility!
- Christa
You NEED to try this supplement
Our high energy border collie is turning eight this year and we want to make sure we are taking the best care of his joints that we can. We had been looking for a joint chew with krill and we have been really happy with PupFlex.
- Arlo
Excited for this
PupFlex+ made a big difference for my dog’s mobility. He used to show some stiffness after long walks, but after a few weeks of using these chews, he’s much more active and moves with ease.
- Kamila S.






Crafted with Premium, Clinically Proven Ingredients
Formulated with the highest-quality, science-backed ingredients to support your dog’s joint health and mobility.
Committed to Premium Quality
Our team of scientific experts ensures every step of our product innovation meets the highest standards.

Third-Party Lab Tested

90 Days Satisfaction Gurantee

Manufactured In USA

GMP Certified

Non-GMO

Vet Approved

Frequently Asked Questions
What does BioPup™ mean?
BioPup™ is a combination of the words bioavailability and pup. Bioavailability is the extent to which a nutrient becomes completely available to its intended biological destination - in this case, your dog!
Doesn’t my dog get all the necessary nutrients in their food?
Your dog does not get all of the active nutrients they need from their food alone. When we assume they get everything they need from their diet, dogs miss out on additional health benefits that target specific health conditions. They also don’t get antioxidants and anti-inflammatory ingredients, joint support, and more. Aside from being repetitive and flavorless oftentimes, your dog’s food isn’t doing more for them when it comes to their nutrition. Supplements with active ingredients can help dogs absorb more nutrients.
Why and when should I give my dog supplements?
You can start giving your dog supplements when they’re a puppy for preventative care if they’re a working or sport dog to recover, or a senior dog who needs support in their older age. Dogs of all ages benefit from bioavailability with BioPup.
What are the concerns that would require me to give my dog
BioPup Canine Functional Joint Health complex?
Osteoarthritis can occur in different parts of your dog’s body: hip joints (hip dysplasia), elbow joints (elbow dysplasia), ankles, knees, and spine. BioFlexine helps keep joints healthy in active and athletic dogs, and it’s beneficial for aging dogs improving their quality of life and freedom of movement. It can also help with post-injury recovery.
Is PupFlex+ recommended by veterinarians?
Yes! PupFlex+ was reviewed, tested, certified and recommended by veterinarians from a VCPR - Veterinary Client-Patient Relationship organization. Our VetEvaluated seal confirms quality of the product.
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