PupFlex+® — Advanced Joint & Mobility Support
Joint Comfort • Mobility & Flexibility • Cartilage Support • Joint Lubrication
Build Your Dog’s Ideal Plan
“PupFlex+ works! And it works fast. Most of my patients showed noticeable improvement in energy and mobility within just 2-4 weeks.”
Dr. Keith True, DVM
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Under 25 lbs
25 - 75 lbs
Over 75 lbs
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Key Ingredients
UC-II® Undenatured Type ll Collagen is clinically proven to support cartilage structure, mobility, and flexibility. Clinical studies have shown UC-ll to be more effective than glucosamine. UC-ll shown reduction of joint discomfort by 57% and exercise-associated lameness by 53% in just 30 days**.
CurcuVet® Curcumin Phytosome® Not ordinary curcumin. This highly bioavailable phytosome form is designed for enhanced absorption and supports a healthy inflammatory response, antioxidant defenses, and everyday joint comfort.
ApresFlex® Boswellia Serrata AKBA extract is a clinically studied, standardized Boswellia extract rich in AKBA that supports a healthy inflammatory response, helps maintain joint & connective tissue comfort and function-especially through everyday activity.
QrillPet™ Antarctic Krill is a highly bioavailable source of EPA and DHA Omega-3 fatty acids in phospholipid form, providing nutritional support for healthy joints and an active lifestyle.
AstaReal® Astaxanthin is a powerful natural antioxidant that helps defend against oxidative stress while supporting joint, muscle, brain, eye, and skin health. Whole-body antioxidant support in every chew.
Supports healthy synovial fluid, natural joint lubrication, and cushioning-helping keep movement smooth and comfortable.
Benefits
PupFlex+® combines six advanced, science-backed ingredients selected to support multiple pathways involved in joint health, mobility, and healthy aging. This comprehensive formula works synergistically to:
• Support healthy joint function & mobility
• Maintain flexibility & everyday comfort
• Support joint lubrication & cushioning
• Maintain healthy cartilage & connective tissue
• Provide powerful antioxidant support
• Suport mobility & recovery in active dogs
What To Expect
3 Weeks
You may begin to notice subtle changes in everyday movement, comfort, and better mood.
6 Weeks
You can see that your dog is more comfortable; less stiffness getting up, longer walks, easier time with stairs, more play time and zoomies.
3 Months & Beyond
Consistent daily use of PupFlex+® provides long lasting results for your pup's joint comfort, flexibility and healthy movement.
Ingredients Info
Active ingredients per soft chew (3g):
QrillPet ™ Dried Antarctic Krill
750 mg
Providing Omega-3 Fatty Acids
16 mg
EPA
30 mg
DHA
9 mg
Astaxanthin
0.06 mg
CurcuVET®(Curcuma longa extract (root) Phospholipid Complex from Sunflower)
75 mg
AprèsFlex®Boswellia serrata (gum resin) extract [std. to 20% 3-0-acetyl-11-keto-ß-boswellic acid (AKBA)]
25 mg
UC-II® (Undenatured Type II Collagen)
20 mg
Hyaluronic Acid (High molecular weight)
10 mg
AstaReal® Astaxanthin
(Haematococcus pluvialis algae extract)
1 mg
Inactive Ingredients:
Acacia Gum, Citric Acid, Coconut Glycerin, Flaxseed Oil, Honey, Mixed Tocopherols, Natural Veggie Flavor, Psyllium Husk, Pumpkin, Rosemary Leaf Extract, Sunflower Lecithin, Vinegar, Water, White Rice Flour.
*Individual results may vary and can take up to 90 days of daily supplementation.
Directions For Use
Meet the Six Research-backed Actives
We've brought together the most advanced joint-supporting ingredients available today:
LEARN MORE
PupFlex+®
Typcal glucosamine chew
Active ingredients
6 clinically studied
3
UC-II® collagen
Yes
No
Bioavailable curcumin (CurcuVet®)
Yes
No
Multi-pathway support for joint cartilage, connective tissue and beyond
Yes
No
Supports comfort in the short and long term
Yes
No
Third-party tested and NASC member
Yes
Varies
Why Settle for 20-Year-Old Science? Most joint chews stop at glucosamine. PupFlex+® goes further.
Trusted by Veterinarians
Advanced ingredients. Veterinary expertise. Rigorous testing. PupFlex+® brings them together in one science-driven daily joint formula.
Early intervention is life-changing
Joint Support For Every Stage Of Their Story
Senior Dogs
Support comfortable movement and mobility so they can keep enjoying the things they love.
Active Dogs
Help maintain healthy mobility and flexibility through every walk, run, jump, and zoomie.
Young Dogs (>12 Weeks)
Start healthy joint support early, especially for growing and larger dogs.
Working & Performance Dogs
Support hardworking joints through demanding activity, training, everyday movement, and recovery.
Made With Standards You Can Trust
Proudly made in the USA, independently tested, and veterinarian formulated-because quality is at the heart of every BioPup™ formula.
NASC Quality Seal
BioPup™ follows rigorous NASC standards for quality, accurate labeling, and product testing-from formulation to finished product.
VetEvaluated® Certified
Reviewed and tested through a veterinarian-founded certification program focused on pet product quality and safety.
Manufactured to GMP Standards
Produced under strict manufacturing procedures for quality and consistency.
Third Party Lab Tested
Independently tested to verify quality, purity, and label accuracy.
Frequently Asked Questions
Your dog does not get all of the active nutrients they need from their food alone. When we assume they get everything they need from their diet, dogs miss out on additional health benefits that target specific health conditions.
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Doesn’t my dog get all the necessary nutrients in their food?
Your dog does not get all of the active nutrients they need from their food alone. When we assume they get everything they need from their diet, dogs miss out on additional health benefits that target specific health conditions. They also don’t get antioxidants and anti-inflammatory ingredients, joint support, and more. Aside from being repetitive and flavorless oftentimes, your dog’s food isn’t doing more for them when it comes to their nutrition. Supplements with active ingredients can help dogs absorb more nutrients.
Why and when should I give my dog supplements?
You can start giving your dog supplements when they’re a puppy for preventative care if they’re a working or sport dog to recover, or a senior dog who needs support in their older age. Dogs of all ages benefit from bioavailability with BioPup.
What are the concerns that would require me to give my dog
BioPup™ Canine Functional Joint Health complex?
Osteoarthritis can occur in different parts of your dog’s body: hip joints (hip dysplasia), elbow joints (elbow dysplasia), ankles, knees, and spine. BioFlexine helps keep joints healthy in active and athletic dogs, and it’s beneficial for aging dogs improving their quality of life and freedom of movement. It can also help with post-injury recovery.
Is PupFlex+® recommended by veterinarians?
Yes! PupFlex+® was reviewed, tested, certified and recommended by veterinarians from a VCPR - Veterinary Client-Patient Relationship organization. Our VetEvaluated seal confirms quality of the product.