Joint Health & Mobility Soft Chews For Dogs
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Supports cartilage structure & mobility
Helps manage stiffness for daily comfort
Greater efficacy than Glucosamine & Chondroitin*
6 Clinically studied ingredients
Choose your dog's weight
ADD TO CART - $62.99
/2 months
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Supports Joint Mobility
Helps Reduce Stiffness & Promotes Joint Comfort
Supports Cartilage & Connective Tissue Health
Science-Backed Active Ingredients
PupFlex+ Ingredients
Directions of Use
Real Dog Owners. Real Results. Real Stories
Rated 4.5 out of 5 by over 1,000+ pet parents like you.
5 Powerful Reasons Every Pet Parent Needs to Try PupFlex+ for Their Dog’s Joint Health
Watching your beloved pup struggle with stiff joints and reduced mobility is heartbreaking. Every pet parent wants their furry companion to live an active, pain-free life—but finding a truly effective joint supplement can feel impossible.
That’s why thousands of dog owners are turning to PupFlex+, a premium joint support supplement designed to promote long-term mobility, flexibility, and comfort.
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Helps With:
Cushioning and Lubricating Joints
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Joint Stiffness & Comfort
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Mobility & Flexibility
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Cartilage & Connective Tissue Support
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Healthy Inflammatory Response
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Powerful Antioxidant Protection
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Better Mood & Improved Energy Level
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Cushioning and Lubricating Joints
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Joint Stiffness & Comfort
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Mobility & Flexibility
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Cartilage & Connective Tissue Support
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Healthy Inflammatory Response
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Powerful Antioxidant Protection
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Better Mood & Improved Energy Level
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1. Clinically Proven Ingredients for Maximum Joint Support
Not all joint supplements are created equal. PupFlex+ stands out because it’s packed with scientifically backed ingredients, including UC-II® (Undenatured Type II Collagen), CurcuVet® (Curcumin Phytosome®), ApresFlex® (Boswellia Serrata AKBA extract), Antarctic Krill Omega-3 and AstaReal® Astaxanthin.
These powerful actives work synergistically to support joint comfort, promote flexibility, maintain healthy cartilage & connective tissue, and help preserve overall joint function — so dogs of all breeds, sizes, and ages can keep moving with confidence and ease.
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2. Fast-Acting Formula – See Results in Just 3 Weeks
Many pet parents get discouraged by supplements that take months to show any changes- if they work at all. With PupFlex+, most dog owners report seeing positive changes in their dog’s mobility and ease of movement within just 3-4 weeks.* This is thanks to high-bioavailability and potency of our premium active ingredients, which begin supporting joint flexibility, healthy movement, and overall comfort faster than traditional Glucosamine & Chondroitin-based formulas.
3. Ultimate Joint support and protection for effortless movement
UC-ll® Collagen supports cartilage structure, improves mobility and joint comfort by 62% in 30 days*, promotes healthy mobility and flexibility. CurcuVet® (Curcumin Phytosome®) supports joint comfort and healthy inflammatory response. It is shown to be 29 times more bioavailable than other curcumin extracts. ApresFlex®( Boswellia Serrata AKBA) helps maintain everyday joint comfort and supports structural integrity of joints and connective tissue. QrillPet™ Antarctic Krill provides a highly absorbable source of Omega-3 fatty acids that help support joint function and overall mobility. Hyaluronic Acid helps cushion and lubricate joints, supporting synovial fluid production for smoother movement.
4. Powerful Antioxidant Protection for Long-Term Mobility & Wellness
Oxidative stress can affect joint comfort and overall mobility over time. PupFlex+ includes AstaReal® Astaxanthin, one of the most researched and potent natural antioxidants available. It is 6000 times stronger than vitamin C. With continued use, this antioxidant support helps maintain healthy joints, comfortable movement, enhances muscle health, boosts energy level- giving your pup long-term mobility and vitality they deserve.
5. Perfect for Every Dog – From Playful Puppies to Aging Seniors
Whether you have a high-energy pup, a working dog, or a senior companion slowing down with age, PupFlex+ is formulated to support their joint health at every life stage.
Early supplementation helps maintain flexibility and support lifelong mobility, while older dogs benefit from reduced stiffness and improved comfort—making every tail wag a little easier.
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The #1 Choice For Pet Parents
See why thousands of customers trust Biopup
Effective joint support
Our oldest dog Molson (7) was diagnosed with arthritis and once he started taking these, we saw a noticeable difference in his mobility!
- Christa
You NEED to try this supplement
Our high energy border collie is turning eight this year and we want to make sure we are taking the best care of his joints that we can. We had been looking for a joint chew with krill and we have been really happy with PupFlex.
- Arlo
Excited for this
PupFlex+ made a big difference for my dog’s mobility. He used to show some stiffness after long walks, but after a few weeks of using these chews, he’s much more active and moves with ease.
- Kamila S.
Crafted with Premium, Clinically Proven Ingredients
Formulated with the highest-quality, science-backed ingredients to support your dog’s joint health and mobility.
Committed to Premium Quality
Our team of scientific experts ensures every step of our product innovation meets the highest standards.
Third-Party Lab Tested
90 Days Satisfaction Gurantee
Manufactured In USA
GMP Certified
Non-GMO
Vet Approved
*UC-II Combo Supplement; UC-II Mechanism of Action; UC-II Anti-Inflammatory Effects; UC-II Pain Reduction, UC-II Immune Suppression, UC-II vs. Pharma, UC-II Review
*Results based on customer feedback. Individual results may vary.
Frequently Asked Questions
What does BioPup™ mean?
BioPup™ is a combination of the words bioavailability and pup. Bioavailability is the extent to which a nutrient becomes completely available to its intended biological destination - in this case, your dog!
Doesn’t my dog get all the necessary nutrients in their food?
Your dog does not get all of the active nutrients they need from their food alone. When we assume they get everything they need from their diet, dogs miss out on additional health benefits that target specific health conditions. They also don’t get antioxidants and anti-inflammatory ingredients, joint support, and more. Aside from being repetitive and flavorless oftentimes, your dog’s food isn’t doing more for them when it comes to their nutrition. Supplements with active ingredients can help dogs absorb more nutrients.
Why and when should I give my dog supplements?
You can start giving your dog supplements when they’re a puppy for preventative care if they’re a working or sport dog to recover, or a senior dog who needs support in their older age. Dogs of all ages benefit from bioavailability with BioPup.
What are the concerns that would require me to give my dog
BioPup Canine Functional Joint Health complex?
Osteoarthritis can occur in different parts of your dog’s body: hip joints (hip dysplasia), elbow joints (elbow dysplasia), ankles, knees, and spine. BioFlexine helps keep joints healthy in active and athletic dogs, and it’s beneficial for aging dogs improving their quality of life and freedom of movement. It can also help with post-injury recovery.
Is PupFlex+ recommended by veterinarians?
Yes! PupFlex+ was reviewed, tested, certified and recommended by veterinarians from a VCPR - Veterinary Client-Patient Relationship organization. Our VetEvaluated seal confirms quality of the product.
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