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PupFlex+® — Most Advanced Joint Health & Mobility Supplement
High Bioavailability • Multi-Pathway Support • Fast-Acting Comfort • Complete Joint Health
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Key Ingredients
UC-II® Undenatured Type ll Collagen is clinically proven to support cartilage structure, mobility, and flexibility. Clinical studies have shown UC-ll to be more effective than glucosamine. UC-ll shown reduction of joint discomfort by 57% and exercise-associated lameness by 53% in just 30 days.
CurcuVET® Curcumin Phytosome™ is a highly bioavailable form of Curcumin. Helps with occasional joint discomfort, supports normal inflammatory response.
ApresFlex® Boswellia Serrata AKBA extract is clinically proven to reduce occasional joint discomfort, supports structural integrity of joints and connective tissue.
QrillPet™ Antarctic Krill is a source of highly bioavailable anti-inflammatory Omega 3 fatty acids DHA and EPA.
AstaReal® Astaxanthin supports joint and muscle health with protection from free radicals and nitrous oxide. It also supports brain, eye, and skin health.
High Molecular Weight Hyaluronic Acid supports joint flexibility and viscosity of synovial fluids. It cushions and lubricates the joints to promote free range of motion.
Benefits
PupFlex+® combines six advanced, science-backed ingredients selected to support multiple pathways involved in joint health, mobility, and healthy aging. This comprehensive formula works synergistically to:
• Support healthy joint function & mobility
• Maintain flexibility & everyday comfort
• Support joint lubrication & cushioning
• Maintain healthy cartilage & connective tissue
• Provide powerful antioxidant support
• Suport mobility & recovery in active dogs
What To Expect
2 Weeks
You may begin to notice subtle changes in everyday movement, comfort., and better mood.
4 Weeks
You can see that your dog is more comfortable; less stiffness getting up, longer walks, easier time with stairs, more play time and zoomies.
2 Months & Beyond
Consistent daily use of PupFlex+® provides long lasting results for your pup's joint comfort, flexibility and healthy movement.
Ingredients Info
Active ingredients per soft chew (3g):
QrillPet ™ Dried Antarctic Krill
750 mg
Providing Omega-3 Fatty Acids
16 mg
EPA
30 mg
DHA
9 mg
Astaxanthin
0.06 mg
CurcuVET®(Curcuma longa extract (root) Phospholipid Complex from Sunflower)
75 mg
AprèsFlex®Boswellia serrata (gum resin) extract [std. to 20% 3-0-acetyl-11-keto-ß-boswellic acid (AKBA)]
25 mg
UC-II® (Undenatured Type II Collagen)
20 mg
Hyaluronic Acid (High molecular weight)
10 mg
AstaReal® Astaxanthin
(Haematococcus pluvialis algae extract)
1 mg
Inactive Ingredients:
Acacia Gum, Citric Acid, Coconut Glycerin, Flaxseed Oil, Honey, Mixed Tocopherols, Natural Veggie Flavor, Psyllium Husk, Pumpkin, Rosemary Leaf Extract, Sunflower Lecithin, Vinegar, Water, White Rice Flour.
*Individual results may vary and can take up to 90 days of daily supplementation.
Directions For Use
Meet the Six Research-backed Actives
We've assembled the most advanced joint-supporting ingredients available today:
LEARN MORE
PupFlex+®
Typcal glucosamine chew
Active ingredients
6 clinically studied
3
UC-II® collagen
Yes
No
Bioavailable curcumin (CurcuVet®)
Yes
No
Treats root cause instead of just masking symptoms
Yes
No
Supports comfort in the short and long term
Yes
No
Third-party tested and NASC member
Yes
Varies
Why Settle for 20-Year-Old Science? Most joint chews stop at glucosamine. PupFlex+® goes further.
Trusted by Veterinarians
PupFlex+® is formulated with clinically proven active ingredients. Our soft chews are tested and certified by VetEvaluated® team of veterinarians.
Early intervention is life-changing
No Matter Your Dog's Age or Activity Level, Their Joints Deserve Support.

Young Dogs
(>12 Weeks)
Start healthy joint support early, especially for growing and larger dogs.
Active Dogs
Help maintain healthy mobility and flexibility through every walk, run, jump, and zoomie.
Senior Dogs
Support comfortable movement and mobility so they can keep enjoying the things they love.
Working & Performance Dogs
Support hardworking joints through demanding activity, training, everyday movement, and recovery.
Made With Standards You Can Trust
BioPup™ is made in the USA with rigorous quality standards, third-party testing, and veterinary review behind every formula.

NASC Quality Seal
Made by a company that meets rigorous NASC quality, labeling, and testing standards.

VetEvaluated® Certified
Reviewed through a veterinarian-founded certification program focused on pet product quality and safety.

Manufactured to GMP Standards
Produced under strict manufacturing procedures for quality and consistency.

Third Party Lab Tested
Independently tested to verify quality, purity, and label accuracy.
Frequently Asked Questions
Your dog does not get all of the active nutrients they need from their food alone. When we assume they get everything they need from their diet, dogs miss out on additional health benefits that target specific health conditions.
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Doesn’t my dog get all the necessary nutrients in their food?
Your dog does not get all of the active nutrients they need from their food alone. When we assume they get everything they need from their diet, dogs miss out on additional health benefits that target specific health conditions. They also don’t get antioxidants and anti-inflammatory ingredients, joint support, and more. Aside from being repetitive and flavorless oftentimes, your dog’s food isn’t doing more for them when it comes to their nutrition. Supplements with active ingredients can help dogs absorb more nutrients.
Why and when should I give my dog supplements?
You can start giving your dog supplements when they’re a puppy for preventative care if they’re a working or sport dog to recover, or a senior dog who needs support in their older age. Dogs of all ages benefit from bioavailability with BioPup.
What are the concerns that would require me to give my dog
BioPup™ Canine Functional Joint Health complex?
Osteoarthritis can occur in different parts of your dog’s body: hip joints (hip dysplasia), elbow joints (elbow dysplasia), ankles, knees, and spine. BioFlexine helps keep joints healthy in active and athletic dogs, and it’s beneficial for aging dogs improving their quality of life and freedom of movement. It can also help with post-injury recovery.
Is PupFlex+® recommended by veterinarians?
Yes! PupFlex+® was reviewed, tested, certified and recommended by veterinarians from a VCPR - Veterinary Client-Patient Relationship organization. Our VetEvaluated seal confirms quality of the product.
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