

SCIENCE & INGREDIENTS
Better Ingredients for Better Mobility
PupFlex+® is unique in that it contains the most studied, clinically proven nutraceuticals in one single product. Help your dog feel better by maintaining & restoring normal mobility. PupFlex+® soft chews are made with all-natural, and Non-GMO ingredients.
The PupFlex+ Solution
High Bioavailability • Multi-Pathway Support • Fast-Acting Comfort • Complete Joint Health
Made With Standards You Can Trust
BioPup™ is made in the USA with rigorous quality standards, third-party testing, and veterinary review behind every formula.
NASC Quality Seal
Made by a company that meets rigorous NASC quality, labeling, and testing standards.

VetEvaluated® Certified
Reviewed through a veterinarian-founded certification program focused on pet product quality and safety.

Manufactured to GMP Standards
Produced under strict manufacturing procedures for quality and consistency.

Third Party Lab Tested
Independently tested to verify quality, purity, and label accuracy.
INGREDIENTS & SCIENCE
Changing the Narrative on Canine Joint Health
PupFlex+® is a science-driven supplement that covers multiple bases for your dog’s joint health: cartilage structure support, antioxidant protection from free radicals damage, healthy inflammatory response, joint fluid viscosity, pain, and discomfort management to support free range of motion.
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Dr. Firstname Lastname, DVM
Understanding the Impact
Factors such as age, normal wear & tear from everyday activities, and cartilage microtraumas from running & jumping can take a toll on a dog's health, and good nutrition alone isn't the solution. By most estimates, 40% of all dogs—regardless of age or breed, are affected by joint and mobility discomfort. It’s possible that 80% of dogs will show x-ray evidence of the joint problems in their lifetime, which makes mobility and joint discomfort the most common issue that dogs suffer from.
Unfortunately, mobility issues can progress over time. Preventing development by maintaining a healthy body weight with a good diet and appropriate exercise, and administering a high-quality protective joint supplement such as PupFlex+®, is the best way to keep your dog’s joints healthy.
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THE PUPFLEX+® SOLUTION
We Use Better Active Ingredients for a Reason.
The ingredients used in PupFlex+® are more bioavailable, backed by science, and beneficial for dog’s health. We found that supplements currently on the market don’t focus on bioavailability, active ingredient composition, quality of ingredients, or proper dosing. We had to do something different!
THE PUPFLEX+® SOLUTION
We Use Better Active Ingredients for a Reason.
The ingredients used in PupFlex+® are more bioavailable, backed by science, and beneficial for dog’s health. We found that supplements currently on the market don’t focus on bioavailability, active ingredient composition, quality of ingredients, or proper dosing. We had to do something different!

Undenatured Type II Collagen
UC-II®
NATURALLY DERIVED
Undenatured Type II Collagen supports cartilage structure, mobility, and flexibility. Clinical studies proved UC-II to be over 50% more effective than glucosamine for joint health.
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Curcumin Phytosome®
CurcuVet®
FROM TURMERIC
Curcumin Phytosome® helps reduce inflammation and occasional discomfort. It is 29 times more potent & bioavailable than most curcumin extracts.
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Antarctic Krill
QrillPet®
SUSTAINABLY SOURCED
Antarctic Krill is a source of highly bioavailable krill oil from dried krill and the source of anti-inflammatory Omega 3 fatty acids DHA and EPA. Studies showed that krill oil provided improved absorption of omega-3 fatty acids compared to fish oil.
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Boswellia Serrata AKBA Extract
ApresFlex®
PLANT BASED
Boswellia Serrata AKBA extract. It is clinically proven to ease joint discomfort and inflammation, supports structural integrity of joints and connective tissue. Shown to reduce joint pain in 5 days in human clinical trials. AprèsFlex, in combination with CurcuVET®, can protect against the degradation of collagen, which is an important component of connective tissue.
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Astaxanthin
AstaReal®
RED ALGAE EXTRACT
Astaxanthin is the king of carotenoids. It is a powerful antioxidant that is 6000 times more potent than vitamin C, 550 times better at fighting free radicals than vitamin E, and 600 times stronger than CoQ10. AstaReal® Astaxanthin supports joint and muscle health with protection from free radicals and nitrous oxide. Additional benefits: Supports heart, brain and eyes health, improves mitochondrial function.
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Hyaluronic Acid
High Molecular Weight
NATURALLY DERIVED
High molecular weight Hyaluronic Acid supports joint flexibility and viscosity of synovial fluids. It cushions and lubricates the joints to promote free range of motion.
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