The Scientifically-Backed Supplement

The ‘Bio’ in BioPup™ represents bioavailability. The word bioavailability refers to the amount and speed at which a nutrient is absorbed & utilized by the body after it's been ingested—in this case, your ‘Pup’!

PupFlex+ incorporates active ingredients that are scientifically proven to improve a dog's joint health & mobility into a delicious glycerin-free soft chew.

image highlighting impact on dog joints

Understanding the Impact

Factors such as age, normal wear & tear from everyday activities, and cartilage microtraumas from running & jumping can take a toll on a dog's health, and good nutrition alone isn't the solution. By most estimates, 25% of all dogs—regardless of age or breed, are affected by osteoarthritis. It’s possible that 60% of dogs will show x-ray evidence of the disease in their lifetime, which makes osteoarthritis the most common chronic disease that dogs suffer from.

Unfortunately, mobility issues can progress over time. Preventing development by maintaining a healthy body weight with a good diet and appropriate exercise, and administering a high-quality protective joint supplement such as PupFlex+, is the best way to keep your dog’s joints healthy.


  • Large or giant breeds, such as German ShepherdsLabrador Retrievers, Golden Retrievers, Rottweilers, Boxers, and Great Danes
  • Small and medium breeds, such as Dachshunds, French bulldogs, or Basset Hounds
  • Dogs who are obese or are experiencing improper nutrition
  • Middle-aged to senior dogs of all breeds
  • Dogs with poor conformation
  • Dogs who experience repetitive stress from athletic activities like agilityflyball, diving, or protection sports
  • Dogs with injuries such as fractures or ligament tears
  • Dogs with a prior diagnosis of hip or elbow dysplasia
  • Dogs with infections that affect the joints, such as Lyme Disease
  • Or genetics

The BioPup Solution

With the support of veterinarians, we’ve combined scientifically proven active ingredients into a tasty soft chew for all dogs. We started with providing PupFlex+ to dogs that were showing signs of joint discomfort as well as active athletic dogs that experienced occasional stiffness and discomfort past their workout sessions.

Once we saw promising results, we worked with third-party laboratories and veterinarians for testing to ensure the proper dosage of the active ingredients used as well as their correlated effectiveness. PupFlex+ provides support for dogs’ joint cartilage structure, slows down free radical damage, and helps reduce discomfort & inflammation. By cushioning and lubricating joints, PupFlex+ can maintain and improve mobility & flexibility to help your pup live a happy, active life.