PupFlex+
PupFlex+
PupFlex+
PupFlex+
PupFlex+
PupFlex+
PupFlex+
help your dog experience joint comfort and mobility with advanced bioavailability from biopupTM! directions for use: < 25lbs 1 chew daily, 25-75lbs 2 chews daily, >75lbs 3 chew daily
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PupFlex+

Joint Health & Mobility Soft Chews For Dogs

Joint Health & Mobility Soft Chews For Dogs

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PupFlex+ is the science backed health supplement your dog’s joints have been waiting... read more

PupFlex+ is the science backed health supplement your dog’s joints have been waiting for. We combine six breakthrough ingredients that work like a specialized repair team for your dog's joints—each one chosen because it tackles joint health from a different angle, creating results that outdated supplements simply can't match. The difference? PupFlex+ doesn’t mask discomfort. It helps to rebuild what time and activity have worn down.

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Notice joint comfort improvements 
in just 30 days*

Watch your dog rediscover their natural mobility

Supports normal inflammatory response to assist with stiffness & discomfort

Promotes healthy joint cartilage & connective tissue. Doesn't just mask symptoms

Uses nature's joint oils, Antarctic krill and omega-3s, to lubricate joints

Recommended, tested, and certified by VetEvaluated® veterinarians

More effective than outdated Glucosamine & Chondroitin supplements

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Notice joint comfort improvements 
in just 30 days*

Watch your dog rediscover their natural mobility

Supports normal inflammatory response to assist with stiffness & discomfort

Promotes healthy joint cartilage & connective tissue. Doesn't just mask symptoms

Uses nature's joint oils, Antarctic krill and omega-3s, to lubricate joints

Recommended, tested, and certified by VetEvaluated® veterinarians

More effective than outdated Glucosamine & Chondroitin supplements

Product certification and nutrition labels
Product Facts

Active Ingredients:

QrillPetTM Dried Antarctic Krill 750 mg
Providing Omega-3 Fatty Acids 30 mg
EPA 16 mg
DHA 9 mg
Astaxanthin 0.06 mg
UC-ll®
(Undenatured Type II Collagen)
20 mg
CurcuVET® (Curcuma longa extract (root) Phospholipid Complex from Sunflower) 75 mg
AprèsFlex® Boswellia serrata (gum resin) extract [std. to 20% 3-O-acetyl-11-keto-ദ-boswellic acid (AKBA)] 25 mg
AstaReal® Astaxanthin
(Haematococcus pluvialis algae extract)
1 mg
Hyaluronic Acid
(High molecular weight)
10 mg
Directions of Use
help your dog experience joint comfort and mobility with advanced bioavailability from biopupTM! directions for use: < 25lbs 1 chew daily, 25-75lbs 2 chews daily, >75lbs 3 chew daily

*Individual results may vary and can take up to 90 days of daily supplementation.

Helps With:

Joint Pain and Stiffness
Decreasing Inflammation
Cushioning and Lubricating Joints
Supporting Cartilage Structure
Powerful Antioxidant Protection
Promoting Mobility & Flexibility
Joint Pain and Stiffness
Decreasing Inflammation
Cushioning and Lubricating Joints
Supporting Cartilage Structure
Powerful Antioxidant Protection
Promoting Mobility & Flexibility
Joint Pain and Stiffness
Decreasing Inflammation
Cushioning and Lubricating Joints
Supporting Cartilage Structure
Powerful Antioxidant Protection
Promoting Mobility & Flexibility

Who is PupFlex+ for?

Active dogs, senior dogs, young dogs, performance pups, and working dogs! Support your dog’s joints throughout their entire life. Early supplement administration can maintain and improve mobility, flexibility, and agility throughout your pup’s lifetime.

Helps Reduce

  • Supports healthy joint function & flexibility
  • Supports Joint and connective tissue structure
  • Reduces pain and Inflammation
  • Decreases stiffness & discomfort by promoting joint cushioning & lubrication
  • Provides powerful antioxidant protection
  • May improve athletic performance & recovery

PupFlex+ is formulated with clinically proven ingredients. Learn more about the science behind these ingredients here.

Your Dog’s Joint Transformation Timeline

Week 1
Week 2
Less stiffness, shaking, and cracking joints
Week 3
Week 4
More energetic, actually wants to play again, easier time with stairs
Week 5
Week 6
Week 7
Your dog gets excited when you open the bag, and you enjoy their sustained mobility and comfort for years of adventures together
Long-term:

“Our ten year old lab mix was showing signs of stiffness in her left shoulder, along with some weakness and shaking. After reading about your product, we were excited to give it a try! Your insert said to give it 3 weeks to perhaps see some noticeable difference, but we saw changes in her gait, etc. during the first week. We had been giving her Cosequin with no results at all. Plus, she loves the taste and gobbles them up. Thank you so much for giving us our girl back! ❤️ ”

Sandra C.

The Ingredient Science Revolution Your Dog's Joints Have been Waiting For

The 'Old School' Problem:

Most joint supplements rely on glucosamine and chondroitin—ingredients that were groundbreaking 20 years ago but have since been outpaced by modern science.

The PupFlex+ Solution:

We've assembled the most advanced joint-supporting ingredients available today:
UC-II® (Undenatured Type II Collagen)

Think of this as your dog's joint "reset button"

  • Works with your dog's immune system to to help protect and restore cartilage
  • Clinically proven over 50% more effective than glucosamine & chondroitin
  • Helps restore joint cushioning for free range of motion
CurcuVet® (Curcumin Phytosome®)
  • 29 times more bioavailable than other curcumin extracts
  • Supports normal inflammatory response in the joints
  • Promotes joint comfort & flexibility
QrillPet® Antarctic Krill
  • A source of highly bioavailable Omega-3 fatty acids DHA & EPA
  • Supports healthy inflammatory response and overall health
ApresFlex® (Boswellia Serrata Extract)
  • Helps reduce joint stiffness & discomfort
  • Shown to reduce joint discomfort in 5 days in human clinical trials
  • Supports structural integrity of joints and connective tissue
  • Can help protect against the degradation of collagen, which is an important component of joint cartilage
AstaReal® Astaxanthin
  • Powerful antioxidant- 6000 times stronger than Vitamin C, and 600 times stronger than CoQ10.
  • supports joint and muscle health with protection from free radicals and nitrous oxide.
  • Beneficial for joints, muscles, eyes, brain and heart health
  • May help with athletic performance and recovery
Hyaluronic acid (High Molecular weight)
  • Cushions and lubricates joints from the inside
  • Supports joints' synovial fluid viscosity for easy movement

No Matter
Where Your Dog Is in Life, We Meet Them There

Active Dogs

Keep them performing at their peak with proactive joint support and muscle strenght

Senior Dogs

Help them rediscover comfort and mobility, even in their golden years.

Young Pups

Start joint protection early (especially important for larger breeds)

Performance & working dogs

Support faster recovery and maintain a competitive edge

Duke is obviously feeling better since he started on PupFlex. He runs through the pasture alongside my golf cart, which he was very reluctant to do a short time ago. When I ask him if he wants to go out, his eyes light up and he has a big smile on his face.

Brian G.

Early intervention isn't just smart—it's life-changing.

Starting joint support before problems arise can help your dog maintain their agility, flexibility, and overall well-being for their entire life.
Try PupFlex+ now

Why veterinarians love and trust PupFlex+ for their patients?

PupFlex+ soft chews are formulated with clinically proven active ingredients, meaning that scientists measured dogs’ movement and mobility improvements after giving these nutraceuticals to dogs. Find Scientific Studies here: Ingredients and Science. Additionally, our soft chews are tested and certified by VetEvaluated® team of veterinarians.

Trusted by Veterinarians

“As a holistic veterinarian, I am always looking for safe, novel, effective products that I can offer my patients and PupFlex definitely fits the bill. It is readily accepted by my patients, very palatable, and effective. I highly recommend this supplement.”
Dr. David Gordon, DVM
“I advise my patients to use supplements that contain UC-ll Collagen, an ingredient that has been shown to be very effective for joint support. One product I have found particularly effective is PupFlex Plus. I am excited about this product because it includes comprehensive blend of active ingredients. What’s more impressive how quickly it works!”
Dr. Tomas Infernuso, DVM
“These soft chews are not only effective, but also delicious. If your dog has shown any signs of joint discomfort, or if you want to be proactive about their health, then choose PupFlex+ by BioPup.”
Dr. Katie Revelas, DVM
“As a veterinarian, I’m always looking for the best ways to support my patient’s joint health. While Glucosamine and Chondroitin have been widely used, recent studies are now showing they don’t actually improve mobility or joint health in dogs. That’s why I recommend PupFlex+ with UC-ll Collagen and CurcuVet. PupFlex+ works fast. Most dogs show visible improvements in 3 weeks.”
Dr. Kate Greenberg, DVM
“This product has been our new go-to recommended product for joint health! Great to see that they have incorporated several great ingredients to improve joint supplements.”
SunnySide Veterinary

Joint Support at the Cellular Level

UC-ll® Collagen, AstaReal® Astaxanthin, CurcuVet® Bioavailable Curcumin, ApresFlex® Boswellia Serrata AKBA, QrillPet™ Antarctic Krill and Hyaluronic Acid High Molecular Weight- work together to:

  • Supports normal mobility & flexibility
  • Helps restore joint cartilage & connective tissue
  • Protects joint cartilage from everyday wear and tear
  • Supports healthy inflammatory response
  • Helps reduce joint stiffness & discomfort

Frequently Asked Questions

    Doesn’t my dog get all the necessary nutrients in their food?

    Your dog does not get all of the active nutrients they need from their food alone. When we assume they get everything they need from their diet, dogs miss out on additional health benefits that target specific health conditions. They also don’t get antioxidants and anti-inflammatory ingredients, joint support, and more. Aside from being repetitive and flavorless oftentimes, your dog’s food isn’t doing more for them when it comes to their nutrition. Supplements with active ingredients can help dogs absorb more nutrients.

    Why and when should I give my dog supplements?

    You can start giving your dog supplements when they’re a puppy for preventative care if they’re a working or sport dog to recover, or a senior dog who needs support in their older age. Dogs of all ages benefit from bioavailability with BioPup.

    What are the concerns that would require me to give my dog
    BioPup Canine Functional Joint Health complex?

    Osteoarthritis can occur in different parts of your dog’s body: hip joints (hip dysplasia), elbow joints (elbow dysplasia), ankles, knees, and spine. BioFlexine helps keep joints healthy in active and athletic dogs, and it’s beneficial for aging dogs improving their quality of life and freedom of movement. It can also help with post-injury recovery.

    Is PupFlex+ recommended by veterinarians?

    Yes! PupFlex+ was reviewed, tested, certified and recommended by veterinarians from a VCPR - Veterinary Client-Patient Relationship organization. Our VetEvaluated seal confirms quality of the product.

See All Frequently Asked Questions